Constriction Rings: The Missing Link

Psychological Therapies: The Missing Link in Improving Treatment Adherence in Patients with β-thalassemia Major

Fiscal Space Assessment: A Missing Link in Financing Management of Iran’s Health System

Fiscal Space Assessment: A Missing Link in Financing Management of Iran’s Health System Nader Jahanmehr1,2, Soheila Damiri3*, Reza Goudarzi4, Zhaleh Abdi5 1 School of Management and Medical Education, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2 Prevention of Cardiovascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3 Department of...

Inside-out Z rings--constriction with and without GTP hydrolysis.

The bacterial tubulin homologue FtsZ forms a ring-like structure called the Z ring that drives cytokinesis. We showed previously that FtsZ-YFP-mts, which has a short amphipathic helix (mts) on its C terminus that inserts into the membrane, can assemble contractile Z rings in tubular liposomes without any other protein. Here we study mts-FtsZ-YFP, where the membrane tether is switched to the opp...

Myosin concentration underlies cell size–dependent scalability of actomyosin ring constriction

In eukaryotes, cytokinesis is accomplished by an actomyosin-based contractile ring. Although in Caenorhabditis elegans embryos larger cells divide at a faster rate than smaller cells, it remains unknown whether a similar mode of scalability operates in other cells. We investigated cytokinesis in the filamentous fungus Neurospora crassa, which exhibits a wide range of hyphal circumferences. We f...

Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination.

Embryonic development requires a complex series of relative cellular movements and shape changes that are generally referred to as morphogenesis. Although some of the mechanisms underlying morphogenesis have been identified, the process is still poorly understood. Here, we address mechanisms of epithelial morphogenesis using the vertebrate lens as a model system. We show that the apical constri...